|
KMID : 1145520150010010009
|
|
Journal of Radiopharmaceuticals and Molecular Probes
2015 Volume.1 No. 1 p.9 ~ p.14
|
|
|
Synthetic approaches toward [18F]Fluoromisonidazole as a hypoxia imaging maker
|
|
Kwon Young-Do
Lim Seok-Tae
Jeong Hwan-Jeong
Sohn Myung-Hee
Kim Hee-Kwon
|
|
|
Abstract
|
|
|
|
Hypoxia has been shown in many tumors because of a reduced oxygen condition. A useful approach to detect hypoxia is to use molecular imaging. Positron emission tomography (PET), one of the biomedical molecular imaging tools, is the most common non-invasive technique for providing information about physiological and biological events such as diseases. In order to use the PET technique for healthcare, promising molecular probes such as PET tracers required. [18F]Fluoromisonidazole ([18F]FMISO) is the most widely used in PET tracers for hypoxia. In this review, major developments of the synthetic method of [18F]FMISO are discussed.
|
|
|
KEYWORD
|
|
|
[18F]FMISO, Positron emission tomography, Hypoxia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|